GCHFR antibody

Catalog No. ABIN7880936

This Mouse Monoclonal antibody specifically detects GCHFR in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for GCHFR antibody (ABIN7880936)

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GCHFR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GCHFR-7732

Product Details anti-GCHFR Antibody

Purpose: GCHFR Antibody / GFRP

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human GCHFR protein was used as the immunogen for the GCHFR antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the GCHFR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GCHFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GCHFR

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Alternative Name: GCHFR

Background: GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. Cross-linking experiments have shown that GFRP is usually expressed as a homodimer or pentamer.

UniProt: P30047