Recombinant HAUS7 antibody

Catalog No. ABIN7880957

This Rabbit Monoclonal antibody specifically detects HAUS7 in WB, IHC and IP. It exhibits reactivity toward Human.

Quick Overview for Recombinant HAUS7 antibody (ABIN7880957)

Target: HAUS7 (HAUS Augmin-Like Complex, Subunit 7 (HAUS7))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HAUS7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 30H47

Product Details anti-HAUS7 Antibody

Purpose: HAUS7 Antibody / UCHL5IP

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human UCHL5IP was used as the immunogen for the HAUS7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HAUS7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the HAUS7 antibody at -20oC.

Target Details for HAUS7

Target: HAUS7 (HAUS Augmin-Like Complex, Subunit 7 (HAUS7))

Alternative Name: HAUS7

Background: HAUS7 antibody detects HAUS augmin-like complex subunit 7, a protein encoded by the HAUS7 gene that contributes to mitotic spindle organization. HAUS7 is part of the augmin complex, an eight-subunit assembly that recruits gamma tubulin ring complexes to existing microtubules, amplifying spindle microtubule formation during mitosis. This process ensures accurate chromosome alignment and segregation, supporting genomic stability.

HAUS7 antibody is widely used in cell biology and cancer research. The augmin complex promotes branching microtubule nucleation, a mechanism essential for robust spindle assembly in dividing cells. By detecting HAUS7, researchers can study how spindle architecture is generated and maintained. Disruption of augmin components leads to spindle defects, chromosome missegregation, and aneuploidy, processes often linked to tumorigenesis.

Western blot assays detect HAUS7 protein bands in dividing cell extracts. Immunohistochemistry highlights HAUS7 expression in proliferative tissues, while immunofluorescence maps localization at mitotic spindles. These approaches allow detailed analysis of augmin function in cell division.

HAUS7 and other augmin subunits play roles in neural stem cell division, embryonic development, and tissue regeneration. Their contribution to faithful chromosome segregation highlights their importance for preventing genomic instability and disease. By applying HAUS7 antibody, scientists can investigate mechanisms linking spindle regulation to cancer and developmental disorders.

HAUS7 antibody from NSJ Bioreagents provides dependable specificity for studying microtubule nucleation and spindle organization. Its strong performance across methods ensures accurate detection in diverse research contexts.

UniProt: Q99871