ATRX antibody

Catalog No. ABIN7880992

The Mouse Monoclonal anti-ATRX antibody (Clone 23c) (ABIN7880992) specifically detects ATRX in ELISA. The antibody is reactive with Human samples.

Quick Overview for ATRX antibody (ABIN7880992)

Target: ATRX (helicase 2, X-linked (ATRX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: 23c

Product Details anti-ATRX Antibody

Purpose: ATRX Antibody / RAD54 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant human ATRX protein was used as the immunogen for this ATRX antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ATRX antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, it contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, it predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 i± to mediate chromosomal segregation. Mutations in the gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha-thalassemia or ATRX syndrome.

UniProt: P46100