Recombinant HN1 antibody

Catalog No. ABIN7881004

The Rabbit Monoclonal anti-HN1 antibody (Clone 31J27) (ABIN7881004) specifically detects HN1 in WB, FACS, IF and ICC. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Recombinant HN1 antibody (ABIN7881004)

Target: HN1 (Hematological and Neurological Expressed 1 (HN1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HN1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31J27

Product Details anti-HN1 Antibody

Purpose: HN1 Antibody / JPT1 / Hematological and neurological expressed 1

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human HN1 was used as the immunogen for the HN1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the HN1 antibody at -20oC.

Target Details for HN1

Target: HN1 (Hematological and Neurological Expressed 1 (HN1))

Alternative Name: HN1

Background: HN1 antibody detects Hematological and neurological expressed 1, encoded by the HN1 gene. HN1 is a conserved protein expressed in many tissues and has been implicated in cell growth, differentiation, and signaling. Although its precise biochemical function remains under investigation, research suggests that Hematological and neurological expressed 1 may act as a scaffolding or regulatory protein influencing cytoskeletal organization and signal transduction. HN1 antibody provides an important reagent for characterizing this protein's role in normal physiology and disease contexts, particularly in hematopoietic and neurological systems where it is strongly expressed.

Studies have shown that Hematological and neurological expressed 1 participates in proliferation and survival pathways, potentially through interaction with kinases and growth factor receptors. Detection with HN1 antibody has revealed changes in expression during cell cycle progression and differentiation, supporting the idea that this protein integrates extracellular signals with cellular responses. In hematopoietic cells, HN1 may regulate developmental transitions, while in the nervous system, it is linked to neuronal outgrowth and plasticity. Its broad expression pattern suggests that HN1 contributes to multiple cellular functions beyond its namesake tissues.

In cancer research, HN1 has drawn attention as a marker of poor prognosis in several malignancies. Elevated levels have been reported in breast, lung, and liver cancers, where it correlates with increased proliferation and invasiveness. Research using HN1 antibody has demonstrated that silencing or overexpression of HN1 alters tumor cell behavior, implicating it in oncogenic pathways. Because of its association with tumor growth and survival, Hematological and neurological expressed 1 is being investigated as a potential biomarker and therapeutic target.

HN1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies expression changes under experimental conditions such as growth factor stimulation. Immunohistochemistry demonstrates tissue and tumor specific localization, while immunofluorescence reveals cytoplasmic and nuclear distribution. These applications make HN1 antibody versatile for investigating fundamental biology and translational cancer research.

By supplying validated HN1 antibody reagents, NSJ Bioreagents supports discovery of the functions of Hematological and neurological expressed 1, ensuring that researchers can explore its role in cell signaling, differentiation, and disease progression.

UniProt: Q9UK76