Recombinant HNRNPM antibody

Catalog No. ABIN7881033

The Rabbit Monoclonal anti-HNRNPM antibody is suitable to detect HNRNPM in samples from Human, Mouse and Rat. It has been validated for WB, IHC, IF, ICC and FACS.

Quick Overview for Recombinant HNRNPM antibody (ABIN7881033)

Target: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HNRNPM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 29H77

Product Details anti-HNRNPM Antibody

Purpose: HNRNPM Antibody / heterogeneous nuclear ribonucleoprotein M

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human HNRNPM was used as the immunogen for the HNRNPM antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HNRNPM antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the HNRNPM antibody at -20oC.

Target Details for HNRNPM

Target: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Alternative Name: HNRNPM

Background: HNRNPM antibody recognizes heterogeneous nuclear ribonucleoprotein M, an RNA-binding protein involved in pre-mRNA processing and splicing regulation. HNRNPM is part of the hnRNP family, which associates with nascent transcripts to influence alternative splicing, stability, transport, and translation. This protein is widely expressed and contributes to the regulation of diverse gene expression programs in normal development and stress adaptation.

Research using HNRNPM antibody has linked the protein to cancer progression and metastasis. By regulating alternative splicing of genes related to epithelial-to-mesenchymal transition (EMT), HNRNPM promotes tumor invasiveness and metastatic potential. Elevated expression of HNRNPM has been associated with poor prognosis in breast, colorectal, and liver cancers. Its role in RNA processing makes it a critical factor in understanding how splicing dysregulation contributes to oncogenesis.

Beyond cancer, HNRNPM has been implicated in immune function and neurobiology. Studies suggest roles in regulating splicing of immune-related transcripts and neuronal genes, connecting HNRNPM to autoimmune conditions and neurological disorders. Its widespread impact on RNA metabolism positions HNRNPM as an important regulator of cellular identity and function.

Antibodies against HNRNPM are validated for western blot, immunoprecipitation, immunohistochemistry, and immunofluorescence. Researchers use these reagents to analyze HNRNPM expression, splicing complex assembly, and transcript-specific binding. Clone-based antibodies offer the specificity needed to study this protein within large multi-protein RNA processing complexes.

NSJ Bioreagents offers this HNRNPM antibody for investigations into RNA splicing, cancer biology, and immune regulation.

UniProt: P52272