HDAC1 antibody

Catalog No. ABIN7881059

This Rabbit Polyclonal antibody specifically detects HDAC1 in WB, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for HDAC1 antibody (ABIN7881059)

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HDAC1 Antibody

Purpose: Histone deacetylase 1 Antibody / HDAC1

Sequence: DDESYEAIFK PVMSKVMEMF Q

Purification: Antigen affinity purified

Immunogen: Amino acids DDESYEAIFKPVMSKVMEMFQ were used as the immunogen for the Histone deacetylase 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Histone deacetylase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Histone deacetylase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Alternative Name: Histone deacetylase 1

Background: Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Furukawa et al.(1996) mapped RPD3L1 to 1p34.1 by fluorescence in situ hybridization.

UniProt: Q13547

Pathways: Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis