Recombinant Homeobox C6 antibody

Catalog No. ABIN7881116

This Rabbit Monoclonal antibody specifically detects Homeobox C6 in WB, IF and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant Homeobox C6 antibody (ABIN7881116)

Target: Homeobox C6 (HOXC6)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Homeobox C6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31H41

Product Details anti-Homeobox C6 Antibody

Purpose: HOXC6 Antibody / Homeobox C6

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human HoxC6 was used as the immunogen for the HOXC6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HOXC6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the HOXC6 antibody at -20oC.

Target Details for Homeobox C6

Target: Homeobox C6 (HOXC6)

Alternative Name: HOXC6

Background: HOXC6 antibody is designed to detect homeobox C6, a transcription factor belonging to the highly conserved homeobox (HOX) gene family. HOX proteins play a critical role in embryonic development, body patterning, and organogenesis by regulating gene expression programs that control cell fate and differentiation. HOXC6 in particular is expressed in multiple tissues and has been associated with developmental pathways of the nervous system, skeletal formation, and epithelial differentiation. Like other HOX proteins, it functions as a DNA-binding transcription factor that regulates the transcription of downstream target genes.

HOXC6 antibody is widely used in developmental biology and cancer research. Aberrant expression of HOXC6 has been documented in several malignancies, including prostate, breast, and colorectal cancers. Its altered activity contributes to tumor cell proliferation, invasion, and metastasis by regulating epithelial-mesenchymal transition and transcriptional programs that promote oncogenesis. Reliable detection of HOXC6 protein levels with HOXC6 antibody allows researchers to investigate how this transcription factor supports tumor progression and whether it can serve as a biomarker for aggressive disease.

HOXC6 antibody is suitable for applications such as western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, the antibody specifically recognizes HOXC6 protein bands, enabling comparisons of expression across experimental conditions. In immunohistochemistry, HOXC6 antibody localizes nuclear staining patterns within tissue sections, confirming its role as a transcription factor. Immunofluorescence provides additional resolution, allowing visualization of nuclear expression alongside markers of proliferation and differentiation. These applications make the antibody versatile for both basic research and translational studies.

In cancer biology, HOXC6 antibody provides an important tool to investigate how transcriptional networks are rewired to promote malignant behavior. Studies have shown that HOXC6 can regulate genes involved in cell cycle progression, angiogenesis, and drug resistance. Elevated expression correlates with poor prognosis in several cancer types, making HOXC6 an attractive candidate for therapeutic targeting. Detecting HOXC6 with specific antibodies is therefore critical for both mechanistic research and biomarker development.

Beyond oncology, HOXC6 antibody is useful for developmental studies. During embryogenesis, HOXC6 plays a role in specifying anterior-posterior patterning, ensuring correct structural formation. Its expression in neural and epithelial tissues highlights its importance in differentiation pathways that extend beyond cancer. By detecting HOXC6 during development, researchers can better understand how transcription factors coordinate cell fate decisions and how dysregulation contributes to congenital disorders.

HOXC6 antibody provided by NSJ Bioreagents offers researchers a reliable reagent for dissecting transcriptional regulation in both health and disease. Its specificity ensures accurate recognition across multiple assay formats, enabling detailed investigations into the role of HOXC6 in development and oncogenesis.

UniProt: P09630