Human Papilloma Virus 18 E6 (HPV-18 E6) antibody

Catalog No. ABIN7881129

The Mouse Monoclonal anti-Human Papilloma Virus 18 E6 antibody is suitable to detect Human Papilloma Virus 18 E6 in samples from Human Papillomavirus 18 (HPV-18). It has been validated for IHC (p).

Quick Overview for Human Papilloma Virus 18 E6 (HPV-18 E6) antibody (ABIN7881129)

Target: Human Papilloma Virus 18 E6 (HPV-18 E6)

Reactivity: Human Papillomavirus 18 (HPV-18)

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: HPV18-1297

Product Details

Purpose: HPV18 E6 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: HPV18 E6-i²-galactosidase fusion protein was used as the immunogen for this HPV18 E6 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the HPV18 E6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the HPV18 E6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details

Target: Human Papilloma Virus 18 E6 (HPV-18 E6)

Alternative Name: HPV18 E6

Target Type: Viral Protein

Background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.