Recombinant CDH6 antibody

Catalog No. ABIN7881340

The Rabbit Monoclonal anti-CDH6 antibody is suitable to detect CDH6 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant CDH6 antibody (ABIN7881340)

Target: CDH6 (K-Cadherin (CDH6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CDH6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CDH6-9300R

Product Details anti-CDH6 Antibody

Purpose: Recombinant K-Cadherin Antibody / Cadherin 6 / CDH6

Purification: Protein A/G affinity

Immunogen: Recombinant human Cadherin 6 protein (CDH6) was used as the immunogen for the recombinant K-Cadherin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant K-Cadherin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the recombinant K-Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDH6

Target: CDH6 (K-Cadherin (CDH6))

Alternative Name: K-Cadherin

Background: K-Cadherin antibody targets Cadherin 6, a calcium-dependent cell-cell adhesion molecule encoded by the CDH6 gene and a member of the classical cadherin family. Cadherin 6, also commonly referred to as K-Cadherin, is a single-pass transmembrane glycoprotein predominantly localized to the plasma membrane at adherens junctions, where it mediates homophilic interactions between neighboring cells. CDH6 expression is especially prominent in renal tubular epithelium, select epithelial tissues, and the nervous system, consistent with its role in epithelial organization and tissue morphogenesis.

Functionally, Cadherin 6 contributes to stable epithelial cohesion by linking adjacent cells through calcium-dependent adhesion and coupling to the actin cytoskeleton via catenin complexes. A short functional summary is that CDH6 maintains tissue architecture and epithelial integrity by regulating cell-cell adhesion and polarity. Through these adhesive interactions, K-Cadherin influences epithelial differentiation, cellular migration, and spatial organization during development and tissue maintenance.

At the molecular level, Cadherin 6 contains multiple extracellular cadherin repeat domains responsible for calcium binding and adhesive specificity, a single transmembrane region, and a conserved cytoplasmic tail that interacts with beta-catenin and associated adaptor proteins. These structural features integrate extracellular adhesion with intracellular signaling pathways. K-Cadherin antibody reagents are therefore valuable tools for studying adherens junction biology, epithelial cell behavior, and changes in adhesion dynamics under physiological and pathological conditions. Clone CDH6/9300R is designed to recognize Cadherin 6 and supports consistent detection of CDH6 expression in research applications.

From a biological and disease relevance perspective, altered CDH6 expression has been reported in several cancers, including renal cell carcinoma, ovarian cancer, and thyroid carcinoma, where changes in Cadherin 6 levels may correlate with tumor progression and invasive potential. K-Cadherin is also of interest in developmental biology due to its regulated expression during organogenesis. Clone CDH6/9300R provides a reliable reagent for examining Cadherin 6 expression in studies of epithelial differentiation, cancer biology, and cell adhesion mechanisms.

Developmentally, CDH6 expression is tightly regulated and contributes to tissue-specific patterning and morphogenetic processes, particularly in kidney development. K-Cadherin antibodies from NSJ Bioreagents are supplied for research use to support investigations in epithelial biology, developmental studies, and translational cancer research.

UniProt: P55285

Pathways: Cell-Cell Junction Organization