Recombinant CDH6 antibody

Catalog No. ABIN7881340

The Rabbit Monoclonal anti-CDH6 antibody is suitable to detect CDH6 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant CDH6 antibody (ABIN7881340)

Target: CDH6 (K-Cadherin (CDH6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CDH6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CDH6-9300R

Product Details anti-CDH6 Antibody

Purpose: Recombinant K-Cadherin Antibody / Cadherin 6 / CDH6

Purification: Protein A/G affinity

Immunogen: Recombinant human Cadherin 6 protein (CDH6) was used as the immunogen for the recombinant K-Cadherin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant K-Cadherin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant K-Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDH6

Target: CDH6 (K-Cadherin (CDH6))

Alternative Name: K-Cadherin

Background: This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. This protein may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

UniProt: P55285

Pathways: Cell-Cell Junction Organization