Klotho antibody

Catalog No. ABIN7881446

The Rabbit Polyclonal anti-Klotho antibody (ABIN7881446) specifically detects Klotho in WB. The antibody is reactive with Mouse samples.

Quick Overview for Klotho antibody (ABIN7881446)

Target: Klotho (KL)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Klotho antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Klotho Antibody

Purpose: Klotho Antibody

Predicted Reactivity: Human

Purification: Antigen affinity

Immunogen: Recombinant human Klotho was used as the immunogen for the Klotho antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Klotho antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Klotho antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Klotho

Target: Klotho (KL)

Alternative Name: Klotho

Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). [UniProt]

UniProt: Q9UEF7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding