L1CAM antibody

Catalog No. ABIN7881449

The Mouse Monoclonal anti-L1CAM antibody (Clone SPM275) (ABIN7881449) specifically detects L1CAM in ELISA. The antibody is reactive with Human samples.

Quick Overview for L1CAM antibody (ABIN7881449)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: SPM275

Product Details anti-L1CAM Antibody

Purpose: L1CAM Antibody / NCAM-L1 / CD171 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Homogenous suspension of 16-week human fetal brain cells were used as the immunogen for the L1CAM antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the L1CAM antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the L1CAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: L1CAM

Background: Recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius), 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs), and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

UniProt: P32004

Pathways: Synaptic Membrane