L1CAM antibody

Catalog No. ABIN7881450

This Mouse Monoclonal antibody specifically detects L1CAM in ELISA. It exhibits reactivity toward Human.

Quick Overview for L1CAM antibody (ABIN7881450)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: ELISA

Clone: SPM275

Product Details anti-L1CAM Antibody

Purpose: L1CAM Antibody / NCAM-L1 / CD171

Purification: Protein A/G affinity

Immunogen: Homogenous suspension of 16-week human fetal brain cells were used as the immunogen for the L1CAM antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the L1CAM antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the L1CAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: L1CAM

Background: Recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius), 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs), and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

UniProt: P32004

Pathways: Synaptic Membrane