MAT1A antibody

Catalog No. ABIN7881623

The Rabbit Polyclonal anti-MAT1A antibody (ABIN7881623) specifically detects MAT1A in WB, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MAT1A antibody (ABIN7881623)

Target: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAT1A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-MAT1A Antibody

Purpose: MAT1A Antibody / Methionine adenosyltransferase 1

Sequence: DYQRVVRDTI KHIGYDD

Purification: Antigen affinity purified

Immunogen: Amino acids DYQRVVRDTIKHIGYDD were used as the immunogen for the MAT1A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MAT1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MAT1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MAT1A

Target: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Alternative Name: Mat1a

Background: MAT1A antibody targets Methionine adenosyltransferase 1, encoded by the MAT1A gene. Methionine adenosyltransferase 1 is a cytosolic enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP, representing the primary source of cellular methyl donor in adult liver tissue. MAT1A is the dominant methionine adenosyltransferase isoform in hepatocytes and plays a central role in regulating cellular methylation capacity and metabolic homeostasis.

Functionally, Methionine adenosyltransferase 1 controls intracellular S-adenosylmethionine levels, thereby influencing DNA, RNA, protein, and lipid methylation reactions. Through regulation of methyl group availability, MAT1A indirectly modulates gene expression, chromatin structure, and signaling pathways linked to cellular growth and differentiation. A MAT1A antibody supports studies focused on methylation biology and liver-specific metabolic regulation.

MAT1A expression is highly enriched in adult liver and is markedly reduced or replaced by alternative isoforms in fetal liver and non-hepatic tissues. This tissue-specific expression pattern reflects its role in maintaining differentiated hepatocyte function and metabolic stability. Methionine adenosyltransferase 1 can associate with regulatory proteins and metabolic pathways that coordinate amino acid metabolism with epigenetic and transcriptional control mechanisms.

From a disease-relevance perspective, MAT1A has been extensively studied in liver disease and cancer biology. Reduced MAT1A expression or activity is associated with chronic liver disease, cirrhosis, and hepatocellular carcinoma, where disruption of S-adenosylmethionine homeostasis contributes to altered methylation and cellular transformation. MAT1A dysfunction has also been investigated in oxidative stress responses and metabolic imbalance, underscoring its importance in liver health and disease progression.

At the molecular level, Methionine adenosyltransferase 1 functions as a multimeric enzyme complex and contains conserved catalytic domains required for substrate binding and enzymatic activity. Regulatory mechanisms, including redox state and post-translational modification, can influence enzyme activity and apparent behavior in biochemical assays without altering primary sequence. MAT1A antibody reagents support research applications focused on liver metabolism, methylation-dependent signaling, and disease-associated metabolic dysregulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q00266

Pathways: Mitotic G1-G1/S Phases, M Phase, Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process