Recombinant MSRB3 antibody

Catalog No. ABIN7881624

This Rabbit Monoclonal antibody specifically detects MSRB3 in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant MSRB3 antibody (ABIN7881624)

Target: MSRB3 (Methionine Sulfoxide Reductase B3 (MSRB3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MSRB3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 29M98

Product Details anti-MSRB3 Antibody

Purpose: MSRB3 Antibody / Methionine sulfoxide reductase B3

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human MSRB3 was used as the immunogen for the MSRB3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MSRB3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the MSRB3 antibody at -20oC.

Target Details for MSRB3

Target: MSRB3 (Methionine Sulfoxide Reductase B3 (MSRB3))

Alternative Name: MSRB3

Background: MSRB3 antibody detects methionine sulfoxide reductase B3, a repair enzyme encoded by the MSRB3 gene. MSRB3 belongs to the methionine sulfoxide reductase family, which reduces oxidized methionine residues back to methionine. By repairing oxidatively damaged proteins, MSRB3 contributes to redox regulation, protein quality control, and cellular defense against oxidative stress. MSRB3 exists in two isoforms localized to mitochondria and endoplasmic reticulum, reflecting its broad role in maintaining proteostasis.

MSRB3 antibody is widely applied in studies of redox biology, aging, and hearing research. Mutations in MSRB3 cause autosomal recessive nonsyndromic hearing loss due to impaired protection of auditory cells against oxidative damage. By detecting MSRB3, researchers can explore how oxidative stress contributes to sensory degeneration and how protein repair mechanisms maintain tissue health.

In western blot assays, MSRB3 antibody detects protein bands of expected molecular weight in mitochondrial and ER fractions. Immunohistochemistry highlights expression in cochlea, brain, and liver, while immunofluorescence demonstrates subcellular localization to mitochondria and ER networks. These applications provide detailed analysis of MSRB3 distribution and function.

MSRB3 contributes to cellular stress resistance by repairing oxidized methionine in metabolic and structural proteins. Its protective functions extend to aging, neurodegeneration, and metabolic disease. Dysregulation of MSRB3 has been associated with reduced stress tolerance, enhanced apoptosis, and impaired organ function. By applying MSRB3 antibody, scientists can investigate therapeutic strategies aimed at enhancing protein repair pathways.

MSRB3 antibody from NSJ Bioreagents provides strong specificity for analyzing methionine repair mechanisms and oxidative stress responses. Its reliability across multiple assays makes it a critical reagent for studying redox regulation, aging, and sensory biology.

UniProt: Q8IXL7