MUC5AC antibody (Biotin)

Catalog No. ABIN7881679

The Mouse Monoclonal anti-MUC5AC antibody is suitable to detect MUC5AC in samples from Human, Mouse and Rat. It has been validated for IHC (p).

Quick Overview for MUC5AC antibody (Biotin) (ABIN7881679)

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC5AC antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 45M1

Product Details anti-MUC5AC Antibody (Biotin)

Purpose: MUC5AC Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: An M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient was used as the immunogen for the biotinylated MUC5AC antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the biotinylated MUC5AC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the biotinylated MUC5AC antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

Target Details for MUC5AC

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Alternative Name: MUC5AC

Background: This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.

UniProt: P98088