MSTN antibody

Catalog No. ABIN7881742

The Rabbit Polyclonal anti-MSTN antibody is suitable to detect MSTN in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for MSTN antibody (ABIN7881742)

Target: MSTN (Myostatin (MSTN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSTN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MSTN Antibody

Purpose: GDF8 Antibody / Myostatin

Sequence: SGECEFVFLQ KYPH

Purification: Affinity purified

Immunogen: Amino acids SGECEFVFLQKYPH from the human protein were used as the immunogen for the GDF8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GDF8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GDF8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MSTN

Target: MSTN (Myostatin (MSTN))

Alternative Name: GDF8

Background: Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.

UniProt: O14793