Recombinant NUP107 antibody

Catalog No. ABIN7881860

The Rabbit Monoclonal anti-NUP107 antibody (Clone 29N68) (ABIN7881860) specifically detects NUP107 in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant NUP107 antibody (ABIN7881860)

Target: NUP107 (Nucleoporin 107kDa (NUP107))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NUP107 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 29N68

Product Details anti-NUP107 Antibody

Purpose: NUP107 Antibody / Nucleoporin 107

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human Nup107 was used as the immunogen for the NUP107 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NUP107 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the NUP107 antibody at -20oC.

Target Details for NUP107

Target: NUP107 (Nucleoporin 107kDa (NUP107))

Alternative Name: NUP107

Background: NUP107 antibody detects Nuclear pore complex protein Nup107, encoded by the NUP107 gene. Nup107 is a core scaffold protein of the nuclear pore complex, the large multiprotein structure that spans the nuclear envelope and mediates nucleocytoplasmic transport. This protein is part of the Nup107 160 subcomplex, which is required for nuclear pore assembly, maintenance, and cell cycle regulated dynamics. NUP107 antibody enables detection of this essential nuclear pore component in studies of transport, nuclear envelope biology, and cell cycle control.

Nuclear pore complex protein Nup107 participates in the bidirectional transport of macromolecules, including mRNA, ribonucleoproteins, and proteins with nuclear localization or export signals. The Nup107 complex acts as a scaffold for pore assembly and contributes to nuclear envelope reformation after mitosis. Research using NUP107 antibody has revealed that disruption of this subunit leads to defective pore assembly, impaired nucleocytoplasmic trafficking, and cell cycle arrest. Its fundamental role in nuclear structure makes it indispensable for normal cell physiology.

Mutations or reduced expression of NUP107 have been linked to human disease, particularly nephrotic syndrome and premature ovarian failure. These conditions arise from defective nuclear pore assembly, underscoring the importance of this protein in development and tissue homeostasis. Studies with NUP107 antibody have also associated its dysfunction with cancers, where altered transport may affect oncogene regulation and DNA repair pathways. By examining Nup107 expression, researchers can better understand how nuclear pore biology intersects with human disease.

NUP107 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. Western blotting reveals protein levels in dividing cells, while immunofluorescence shows localization at the nuclear envelope throughout interphase and redistribution during mitosis. Immunohistochemistry highlights expression in kidney, ovary, and other tissues affected by Nup107 mutations. These applications demonstrate the utility of NUP107 antibody in diverse cell biology and pathology research.

By supplying validated NUP107 antibody reagents, NSJ Bioreagents enables investigation of nuclear pore biology, transport mechanisms, and disease associated defects. Detection of Nuclear pore complex protein Nup107 provides a critical means of understanding how nuclear transport supports cellular life and contributes to pathology when disrupted.

UniProt: P57740

Pathways: Protein targeting to Nucleus