Recombinant NUP155 antibody

Catalog No. ABIN7881861

This Rabbit Monoclonal antibody specifically detects NUP155 in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant NUP155 antibody (ABIN7881861)

Target: NUP155 (Nucleoporin 155kDa (NUP155))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NUP155 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 30N56

Product Details anti-NUP155 Antibody

Purpose: NUP155 Antibody / Nucleoporin 155

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human NUP155 was used as the immunogen for the NUP155 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NUP155 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the NUP155 antibody at -20oC.

Target Details for NUP155

Target: NUP155 (Nucleoporin 155kDa (NUP155))

Alternative Name: NUP155

Background: NUP155 antibody recognizes nucleoporin 155, a major component of the nuclear pore complex encoded by the NUP155 gene. Nuclear pore complexes are large protein assemblies embedded in the nuclear envelope that regulate transport of molecules between the nucleus and cytoplasm. NUP155 contributes to the structural integrity of the pore and facilitates trafficking of RNAs, proteins, and signaling molecules.

NUP155 antibody is commonly used in studies of nucleocytoplasmic transport and nuclear architecture. The protein is particularly important for maintaining nuclear envelope stability and selective transport of cargo. Defects in NUP155 impair nuclear pore complex assembly and disrupt gene regulation by altering nucleo cytoplasmic communication.

The antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, NUP155 antibody recognizes protein bands corresponding to the expected molecular weight. Immunohistochemistry shows localization at the nuclear envelope, while immunofluorescence provides fine resolution of subnuclear distribution. These applications make NUP155 antibody versatile for research in molecular biology and cell signaling.

Clinical research has linked NUP155 mutations to atrial fibrillation and sudden cardiac death. The connection underscores the importance of nuclear pore complexes beyond basic transport, showing that nuclear envelope proteins contribute to cardiac rhythm and function. By detecting NUP155, researchers can explore how mutations or altered expression influence disease progression.

Nucleoporins, including NUP155, are increasingly recognized as regulators of gene expression. Their roles extend to chromatin organization, DNA repair, and signal transduction. Dysregulation of nucleoporins has been linked to cancer and developmental disorders. NUP155 antibody provides a tool to investigate how nuclear pore function impacts diverse biological processes.

NUP155 antibody from NSJ Bioreagents provides reliable specificity for analyzing nuclear pore biology, disease pathogenesis, and cellular communication. It is a valuable reagent for laboratories studying nuclear transport and gene regulation.

UniProt: O75694

Pathways: Protein targeting to Nucleus