ODC1 antibody

Catalog No. ABIN7881883

The Mouse Monoclonal anti-ODC1 antibody is suitable to detect ODC1 in samples from Human. It has been validated for IHC (p).

Quick Overview for ODC1 antibody (ABIN7881883)

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ODC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM565

Product Details anti-ODC1 Antibody

Purpose: Ornithine Decarboxylase Antibody

Purification: Protein G affinity chromatography

Immunogen: Recombinant human protein was used as the immunogen for this ODC-1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The optimal dilution of the Ornithine Decarboxylase antibody for each application should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Ornithine Decarboxylase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ODC1

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Alternative Name: Ornithine Decarboxylase

Background: Recognizes a 53 kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

UniProt: P11926