Recombinant Periostin antibody

Catalog No. ABIN7881917

The Rabbit Monoclonal anti-Periostin antibody (Clone POSTN-8951R) (ABIN7881917) specifically detects Periostin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Periostin antibody (ABIN7881917)

Target: Periostin (POSTN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Periostin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: POSTN-8951R

Product Details anti-Periostin Antibody

Purpose: Periostin Antibody

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human POSTN protein was used as the immunogen for the Periostin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Periostin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Periostin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Periostin

Target: Periostin (POSTN)

Alternative Name: Periostin

Background: Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for AlphaVbeta3 and AlphaVbeta5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

UniProt: Q15063