Recombinant PEX11B antibody

Catalog No. ABIN7881918

This Rabbit Monoclonal antibody specifically detects PEX11B in WB and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for Recombinant PEX11B antibody (ABIN7881918)

Target: PEX11B (Peroxisomal Biogenesis Factor 11 beta (PEX11B))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PEX11B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 29P66

Product Details anti-PEX11B Antibody

Purpose: PEX11B Antibody / Peroxisomal membrane protein 11B

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PEX11B was used as the immunogen for the PEX11B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PEX11B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PEX11B antibody at -20oC.

Target Details for PEX11B

Target: PEX11B (Peroxisomal Biogenesis Factor 11 beta (PEX11B))

Alternative Name: PEX11B

Background: PEX11B antibody detects PEX11B, a peroxisomal biogenesis factor encoded by the PEX11B gene. Other names include peroxisomal membrane protein 11B and PMP11B. PEX11B is a peroxisomal membrane protein that regulates peroxisome proliferation and division. It belongs to the PEX11 family, which control peroxisome number and morphology. PEX11B promotes peroxisomal elongation, constriction, and fission, ensuring proper distribution of peroxisomes during cell division and differentiation. Peroxisomes are essential organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis, making PEX11B critical for cellular homeostasis.

PEX11B antibody is widely applied in cell biology, metabolism, and disease research. By detecting PEX11B, researchers can explore how peroxisomes multiply and adapt to metabolic demands. Knockout studies show that PEX11B deficiency leads to reduced peroxisome number, altered lipid metabolism, and developmental abnormalities. This highlights its importance in peroxisome biogenesis disorders.

Applications include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting identifies PEX11B protein in peroxisome enriched fractions, immunohistochemistry maps tissue distribution in liver and kidney, and immunofluorescence highlights peroxisomal membranes. These assays provide robust tools for evaluating peroxisome biology in health and disease.

Mutations in PEX11B cause peroxisome biogenesis disorders characterized by cataracts, intellectual disability, and developmental delay. These disorders illustrate the essential role of PEX11B in organelle maintenance. By applying PEX11B antibody, scientists can investigate peroxisomal dynamics, inheritance, and disease mechanisms. In addition, altered peroxisome function is linked to metabolic syndromes, cancer, and neurodegeneration, making PEX11B relevant beyond rare genetic disease.

PEX11B interacts with dynamin like proteins and other peroxisome fission factors, coordinating peroxisome proliferation with mitochondrial dynamics. This crosstalk underscores its importance in cellular energy balance. NSJ Bioreagents provides PEX11B antibody with strong specificity, supporting accurate detection of this essential peroxisomal protein in both basic and translational studies.

UniProt: O96011