Recombinant Phosphoglucomutase 1 antibody

Catalog No. ABIN7881928

The Rabbit Monoclonal anti-Phosphoglucomutase 1 antibody is suitable to detect Phosphoglucomutase 1 in samples from Human, Mouse and Rat. It has been validated for WB, IF, IP and ICC.

Quick Overview for Recombinant Phosphoglucomutase 1 antibody (ABIN7881928)

Target: Phosphoglucomutase 1 (PGM1)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Phosphoglucomutase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 30P21

Product Details anti-Phosphoglucomutase 1 Antibody

Purpose: PGM1 Antibody / Phosphoglucomutase 1

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human PGM1 was used as the immunogen for the PGM1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PGM1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PGM1 antibody at -20oC.

Target Details for Phosphoglucomutase 1

Target: Phosphoglucomutase 1 (PGM1)

Alternative Name: PGM1

Background: PGM1 antibody detects Phosphoglucomutase 1, encoded by the PGM1 gene. Phosphoglucomutase 1 is a key metabolic enzyme that catalyzes the reversible conversion of glucose-1-phosphate and glucose-6-phosphate, thereby linking glycogen metabolism with glycolysis and gluconeogenesis. PGM1 antibody provides researchers with an important reagent to study carbohydrate metabolism, energy regulation, and metabolic disorders.

Phosphoglucomutase 1 functions as a critical branch-point enzyme, controlling the flux of glucose molecules between storage and utilization pathways. Research using PGM1 antibody has shown that its activity is essential for maintaining blood glucose levels during fasting and feeding cycles. The enzyme is expressed in most tissues, but is particularly abundant in liver and muscle, where it helps balance glycogen reserves with immediate energy needs. This makes Phosphoglucomutase 1 indispensable for metabolic flexibility.

Studies with PGM1 antibody have revealed that deficiency in this enzyme leads to PGM1 deficiency, also known as glycogen storage disease type XIV. Patients present with hypoglycemia, hepatomegaly, exercise intolerance, and sometimes congenital disorders of glycosylation, as the enzyme also contributes to protein glycosylation pathways. Mutations in PGM1 impair enzymatic activity, demonstrating the broad role of this protein in both energy metabolism and protein processing.

In cancer research, Phosphoglucomutase 1 has gained attention as a metabolic regulator. Studies with PGM1 antibody have shown that altered expression levels can reprogram glucose metabolism to support rapid tumor growth. By increasing glycolytic flux and maintaining biosynthetic precursors, PGM1 supports cell proliferation. This positions it as a potential biomarker for metabolic adaptation in cancer.

PGM1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies protein levels and detects isoforms, immunohistochemistry reveals tissue distribution in metabolic organs, and immunofluorescence highlights cytoplasmic localization associated with glycogen granules. These experimental applications make PGM1 antibody valuable in basic and clinical research.

By supplying validated PGM1 antibody reagents, NSJ Bioreagents supports studies into carbohydrate metabolism, inherited disorders, and tumor biology. Detection of Phosphoglucomutase 1 provides insight into how cells balance energy storage with utilization under diverse physiological conditions.

UniProt: P36871

Pathways: Cellular Glucan Metabolic Process