POMC antibody

Catalog No. ABIN7882052

The Rabbit Monoclonal anti-POMC antibody (Clone ADEC-16) (ABIN7882052) specifically detects POMC in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for POMC antibody (ABIN7882052)

Target: POMC (Proopiomelanocortin (POMC))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This POMC antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ADEC-16

Product Details anti-POMC Antibody

Purpose: POMC Antibody / ACTH

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human POMC was used as the immunogen for the POMC antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the POMC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the POMC antibody at -20oC.

Target Details for POMC

Target: POMC (Proopiomelanocortin (POMC))

Alternative Name: POMC

Background: This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [RefSeq]

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour