Recombinant PRMT7 antibody

Catalog No. ABIN7882072

The Rabbit Monoclonal anti-PRMT7 antibody is suitable to detect PRMT7 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Recombinant PRMT7 antibody (ABIN7882072)

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PRMT7 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 29P93

Product Details anti-PRMT7 Antibody

Purpose: PRMT7 Antibody / Protein arginine methyltransferase 7

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PRMT7 was used as the immunogen for the PRMT7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PRMT7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PRMT7 antibody at -20oC.

Target Details for PRMT7

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Alternative Name: PRMT7

Background: PRMT7 antibody detects protein arginine methyltransferase 7, encoded by the PRMT7 gene. This enzyme is also known as HRMT1L2, HMT7, and protein arginine N methyltransferase 7. PRMT7 belongs to the PRMT family, which catalyzes the methylation of arginine residues on histones and non histone proteins. Unlike most PRMTs that catalyze asymmetric dimethylation, PRMT7 is unique in generating symmetric dimethylarginine. This modification regulates chromatin structure, transcription, RNA processing, and signal transduction. PRMT7 localizes to the nucleus and cytoplasm, where it modifies diverse protein substrates.

PRMT7 antibody is widely applied in epigenetics, RNA biology, and cancer research. By detecting PRMT7, researchers can explore how symmetric arginine dimethylation influences chromatin regulation and cellular signaling. PRMT7 activity has been linked to stem cell pluripotency, DNA repair, stress responses, and immune regulation. In embryonic stem cells, PRMT7 maintains self renewal by repressing differentiation associated genes. In DNA repair, PRMT7 modifies proteins such as histone H4, contributing to recruitment of repair complexes.

Applications of PRMT7 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting detects PRMT7 protein in nuclear and cytoplasmic fractions, immunohistochemistry maps expression in tissues such as testis and skeletal muscle, and immunofluorescence highlights dynamic localization in response to stress. These assays provide powerful approaches for analyzing PRMT7 biology across systems.

PRMT7 dysregulation contributes to cancer, immune dysfunction, and developmental syndromes. Amplification or overexpression of PRMT7 has been observed in breast, lung, and hematologic cancers, where it alters gene expression and promotes survival. Loss of PRMT7 function has been associated with intellectual disability syndromes, reflecting its role in neural development. By applying PRMT7 antibody, scientists can investigate how balanced methyltransferase activity is required for normal physiology.

Therapeutically, PRMT7 is a candidate drug target. Inhibitors of PRMT7 are under development to modulate arginine methylation in cancer and immune diseases. Detection of PRMT7 expression by antibody based assays provides biomarkers for preclinical studies and therapeutic development. NSJ Bioreagents offers PRMT7 antibody with strong specificity and reproducibility, supporting both mechanistic and translational studies.

UniProt: Q9NVM4

Pathways: Ribonucleoprotein Complex Subunit Organization