Recombinant PWP1 antibody

Catalog No. ABIN7882112

The Rabbit Monoclonal anti-PWP1 antibody (Clone 30P43) (ABIN7882112) specifically detects PWP1 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant PWP1 antibody (ABIN7882112)

Target: PWP1 (PWP1 Homolog (PWP1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PWP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 30P43

Product Details anti-PWP1 Antibody

Purpose: PWP1 Antibody / Periodic tryptophan protein 1

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human PWP1 was used as the immunogen for the PWP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PWP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PWP1 antibody at -20oC.

Target Details for PWP1

Target: PWP1 (PWP1 Homolog (PWP1))

Alternative Name: PWP1

Background: PWP1 antibody detects Periodic tryptophan protein 1 homolog, encoded by the PWP1 gene. Periodic tryptophan protein 1 homolog is a nucleolar protein implicated in ribosome biogenesis and transcriptional regulation. PWP1 antibody provides researchers with an important tool to study ribosomal assembly, nucleolar function, and growth signaling.

Periodic tryptophan protein 1 homolog localizes predominantly to the nucleolus, where it interacts with ribosomal RNA processing factors. Research using PWP1 antibody has demonstrated that the protein supports maturation of 60S ribosomal subunits, ensuring proper assembly and export of ribosomes to the cytoplasm. Ribosome biogenesis is tightly linked to cellular growth and proliferation, making PWP1 essential for cell viability.

Studies with PWP1 antibody have revealed connections between the protein and growth signaling pathways such as mTOR. PWP1 integrates nutrient and growth factor signals with ribosome production, coordinating protein synthesis capacity with environmental conditions. Dysregulation of PWP1 disrupts this balance, impairing ribosomal biogenesis and cellular metabolism. This positions PWP1 at the crossroads of growth control and ribosome biology.

PWP1 has also been implicated in cancer biology. Research using PWP1 antibody has shown that overexpression supports tumor growth by enhancing ribosome biogenesis and protein synthesis. Elevated levels correlate with poor prognosis in cancers such as hepatocellular carcinoma and breast cancer. Conversely, depletion of PWP1 reduces proliferation and induces apoptosis, highlighting its potential as a therapeutic target.

PWP1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms nucleolar expression, immunohistochemistry reveals enrichment in proliferative tissues, and immunofluorescence highlights nucleolar localization. These applications make PWP1 antibody valuable in studies of nucleolar biology and cancer research.

By supplying validated PWP1 antibody reagents, NSJ Bioreagents supports research into ribosome biogenesis, nucleolar function, and tumor biology. Detection of Periodic tryptophan protein 1 homolog allows researchers to investigate how nucleolar proteins regulate cell growth and disease.

UniProt: Q13610