Recombinant RAB22A antibody

Catalog No. ABIN7882122

This Rabbit Monoclonal antibody specifically detects RAB22A in WB, IP, IF and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant RAB22A antibody (ABIN7882122)

Target: RAB22A (RAB22A, Member RAS Oncogene Family (RAB22A))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RAB22A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31R51

Product Details anti-RAB22A Antibody

Purpose: RAB22A Antibody / Ras related protein Rab-22A

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human RAB22A was used as the immunogen for the RAB22A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RAB22A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the RAB22A antibody at -20oC.

Target Details for RAB22A

Target: RAB22A (RAB22A, Member RAS Oncogene Family (RAB22A))

Alternative Name: RAB22A

Background: RAB22A antibody detects Ras related protein Rab-22A, a member of the Rab family of small GTPases encoded by the RAB22A gene. Rab proteins are key regulators of vesicle trafficking, controlling vesicle formation, motility, tethering, and fusion. RAB22A localizes to early endosomes and recycling endosomes, where it regulates cargo sorting and endosomal membrane dynamics. By cycling between an active GTP bound state and an inactive GDP bound state, RAB22A coordinates membrane trafficking and receptor recycling.

RAB22A antibody is widely applied in studies of endocytosis, membrane trafficking, and receptor regulation. RAB22A interacts with Rabex-5 and Rabaptin-5 to control early endosome maturation and crosstalk with Rab5 mediated pathways. It also contributes to recycling of transferrin receptors and growth factor receptors to the plasma membrane. By detecting RAB22A, researchers can examine how membrane trafficking proteins influence nutrient uptake, receptor signaling, and cellular homeostasis.

Western blot assays identify RAB22A protein bands of expected size in cell and tissue lysates. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence reveals punctate distribution consistent with endosomal localization. These techniques make RAB22A antibody versatile for cell biology research.

Dysregulation of RAB22A has been linked to cancer and neurodegeneration. Elevated RAB22A expression enhances receptor recycling and signaling, promoting tumor cell survival, invasion, and therapy resistance. In neurons, altered RAB22A activity contributes to trafficking defects and synaptic dysfunction. By applying RAB22A antibody, scientists can explore how small GTPases regulate intracellular trafficking and disease mechanisms.

Beyond cancer and neuroscience, RAB22A also participates in immune signaling and pathogen entry. Certain viruses exploit RAB22A regulated endocytosis for infection, highlighting its role in host-pathogen interactions. Its broad biological functions emphasize the importance of RAB22A antibody in both basic and translational research.

RAB22A antibody from NSJ Bioreagents delivers reliable specificity for studying Rab GTPase biology, vesicle trafficking, and signaling. Its strong performance across assays ensures accurate detection in diverse contexts.

UniProt: Q9UL26