RAD21 antibody

Catalog No. ABIN7882129

The Rabbit Monoclonal anti-RAD21 antibody is suitable to detect RAD21 in samples from Human. It has been validated for WB.

Quick Overview for RAD21 antibody (ABIN7882129)

Target: RAD21 (RAD21 Homolog (RAD21))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RAD21 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: CBH-18

Product Details anti-RAD21 Antibody

Purpose: Rad21 Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Rad21 was used as the immunogen for the Rad21 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Rad21 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Rad21 antibody at -20oC.

Target Details for RAD21

Target: RAD21 (RAD21 Homolog (RAD21))

Alternative Name: Rad21

Background: Double-strand-break repair protein rad21 homolog' is a cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. [UniProt]

UniProt: O60216

Pathways: Positive Regulation of Endopeptidase Activity