Renin antibody

Catalog No. ABIN7882151

The Rabbit Polyclonal anti-Renin antibody (ABIN7882151) specifically detects Renin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Renin antibody (ABIN7882151)

Target: Renin (REN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Renin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Renin Antibody

Purpose: Renin Antibody / REN

Sequence: RKFYTEFDRR NNRIGFALAR

Purification: Affinity purified

Immunogen: Amino acids RKFYTEFDRRNNRIGFALAR from the human protein were used as the immunogen for the Renin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Renin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Renin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Renin

Target: Renin (REN)

Alternative Name: Renin

Background: The REN gene encodes Renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.

UniProt: P00797

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour