Recombinant Septin 8 antibody

Catalog No. ABIN7882236

This Rabbit Monoclonal antibody specifically detects Septin 8 in WB, IF, IHC, IP, ICC and FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Recombinant Septin 8 antibody (ABIN7882236)

Target: Septin 8 (SEPT8)

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Septin 8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 30S14

Product Details anti-Septin 8 Antibody

Purpose: SEPTIN8 Antibody / Septin 8

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human Septin 8 was used as the immunogen for the SEPTIN8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SEPTIN8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the SEPTIN8 antibody at -20oC.

Target Details for Septin 8

Target: Septin 8 (SEPT8)

Alternative Name: SEPTIN8

Background: SEPTIN8 antibody detects Septin 8, encoded by the SEPTIN8 gene. Septin 8 is a member of the septin family of GTP binding cytoskeletal proteins involved in cytokinesis, vesicle trafficking, and cellular morphogenesis. SEPTIN8 antibody provides researchers with a specific reagent to study cytoskeletal organization, cell division, and neuronal development.

Septins form hetero oligomeric complexes that polymerize into filaments and higher order structures. Research using SEPTIN8 antibody has shown that Septin 8 contributes to filament assembly, acting as a structural scaffold at the plasma membrane and division sites. Septin complexes coordinate with actin and microtubules to regulate cell polarity and compartmentalization, ensuring proper cell division and morphogenesis.

In neurons, Septin 8 plays roles in dendritic branching and synapse formation. Studies with SEPTIN8 antibody have demonstrated that it localizes to dendritic spines and regulates cytoskeletal rearrangements required for synaptic plasticity. Dysregulation of Septin 8 expression or function may impair neural connectivity and contribute to neurological disorders.

Septin dysregulation has been linked to cancer and neurodegeneration. Research using SEPTIN8 antibody has revealed that abnormal expression influences cell cycle progression, apoptosis, and tumor growth. In the nervous system, altered Septin 8 activity has been associated with psychiatric and developmental disorders, reflecting its importance in synaptic regulation and cytoskeletal dynamics.

SEPTIN8 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies endogenous protein levels, immunohistochemistry highlights expression in proliferative tissues, and immunofluorescence demonstrates cytoskeletal localization. These applications make SEPTIN8 antibody a versatile reagent in cytoskeletal and neuronal research.

By supplying validated SEPTIN8 antibody reagents, NSJ Bioreagents supports studies into cytoskeletal organization, neuronal development, and disease biology. Detection of Septin 8 provides insight into how septin family proteins regulate essential cellular processes.

UniProt: Q92599