Recombinant SRR antibody

Catalog No. ABIN7882239

This Rabbit Monoclonal antibody specifically detects SRR in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant SRR antibody (ABIN7882239)

Target: SRR (Serine Racemase (SRR))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SRR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 30S73

Product Details anti-SRR Antibody

Purpose: SRR Antibody / Serine racemase

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human Serine racemase was used as the immunogen for the SRR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SRR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the SRR antibody at -20oC.

Target Details for SRR

Target: SRR (Serine Racemase (SRR))

Alternative Name: SRR

Background: SRR antibody detects Serine racemase, encoded by the SRR gene. Serine racemase is a pyridoxal phosphate dependent enzyme that catalyzes the conversion of L-serine to D-serine. D-serine functions as a co-agonist at NMDA receptors in the brain, where it modulates synaptic plasticity, learning, and memory. SRR antibody provides researchers with a specific reagent to study neurotransmission, amino acid metabolism, and neuropsychiatric disease.

Serine racemase is expressed primarily in astrocytes and neurons, where it controls production of D-serine in the central nervous system. Research using SRR antibody has shown that D-serine binds to the glycine site of NMDA receptors, regulating receptor activation. This makes SRR activity essential for synaptic plasticity, long-term potentiation, and cognitive function. Loss of D-serine production due to impaired SRR activity results in deficits in NMDA receptor signaling.

Dysregulation of Serine racemase is linked to neurological and psychiatric disorders. Studies with SRR antibody have revealed that reduced activity contributes to schizophrenia by decreasing D-serine availability and NMDA receptor function. Conversely, excessive D-serine production may promote excitotoxicity and neurodegeneration in conditions such as amyotrophic lateral sclerosis and Alzheimer's disease. These findings position SRR as both a biomarker and a potential therapeutic target.

Beyond the brain, Serine racemase contributes to metabolism and signaling in peripheral tissues. Research using SRR antibody has suggested roles in kidney function and immune regulation. Because D-serine influences both neural and systemic physiology, SRR is an enzyme with broad biological significance.

SRR antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full-length and truncated forms, immunohistochemistry highlights expression in brain regions, and immunofluorescence demonstrates astrocytic and neuronal localization. These applications make SRR antibody versatile in neuroscience and physiology research.

By supplying validated SRR antibody reagents, NSJ Bioreagents supports research into neurotransmission, psychiatric disease, and neurodegeneration. Detection of Serine racemase provides insight into how amino acid metabolism intersects with brain signaling and disease.

UniProt: Q9GZT4