Recombinant STK26/MST4 antibody

Catalog No. ABIN7882241

The Rabbit Monoclonal anti-STK26/MST4 antibody (Clone 29S79) (ABIN7882241) specifically detects STK26/MST4 in WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant STK26/MST4 antibody (ABIN7882241)

Target: STK26/MST4 (MST4) (Serine/threonine-Protein Kinase MST4 (MST4))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STK26/MST4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 29S79

Product Details anti-STK26/MST4 Antibody

Purpose: STK26 Antibody / MST4 / MASK

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human MST4 was used as the immunogen for the STK26 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STK26 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the STK26 antibody at -20oC.

Target Details for STK26/MST4

Target: STK26/MST4 (MST4) (Serine/threonine-Protein Kinase MST4 (MST4))

Alternative Name: STK26

Background: STK26 antibody recognizes serine threonine kinase 26, a signaling kinase that participates in cell proliferation, apoptosis, and polarity regulation. STK26, sometimes referred to as MST4 or MASK associated protein, is a member of the germinal center kinase family. It is encoded by the STK26 gene and functions downstream of multiple signaling pathways including the Hippo pathway. Through phosphorylation of substrates involved in cytoskeletal dynamics and transcriptional regulation, STK26 contributes to cellular architecture and growth control.

STK26 antibody is commonly applied in studies of cancer, epithelial polarity, and kinase signaling. In epithelial cells, STK26 regulates apical basal polarity and tissue organization. In cancer, STK26 expression has been associated with tumor progression, migration, and invasion. By detecting STK26 expression, researchers can examine how dysregulation of this kinase influences malignancy and whether it serves as a useful biomarker.

The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, STK26 antibody detects protein bands corresponding to the expected size, confirming expression across different samples. Immunohistochemistry highlights tissue localization of the kinase, while immunofluorescence provides single cell resolution of its cytoplasmic and membrane associated distribution. These applications make STK26 antibody a versatile tool for exploring kinase activity in diverse biological contexts.

Research has shown that STK26 interacts with adaptor proteins such as MASK and kinases like MST4, forming scaffolding complexes that integrate signaling networks. These complexes influence cell polarity, cytoskeletal organization, and transcription factor regulation. STK26 is also implicated in Hippo signaling, a pathway that governs tissue size and cellular proliferation by balancing growth and apoptosis. By using STK26 antibody, scientists can evaluate how this kinase contributes to developmental biology and disease progression.

In oncology, altered STK26 expression has been reported in certain cancers, where its activity may support invasion and metastasis. Experimental models suggest that modulation of STK26 influences tumor cell migration, making it a potential therapeutic target. Beyond cancer, STK26 plays roles in tissue morphogenesis, neuronal polarity, and immune regulation. Antibodies against STK26 therefore support a broad range of research into cellular organization and signaling.

STK26 antibody provided by NSJ Bioreagents offers researchers a specific and dependable reagent for studying kinase mediated signaling, polarity establishment, and cancer biology. Its reliability across multiple applications makes it a valuable resource for laboratories investigating cellular signaling networks.

UniProt: Q9P289