TNNI1 antibody

Catalog No. ABIN7882280

The Rabbit Polyclonal anti-TNNI1 antibody (ABIN7882280) specifically detects TNNI1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for TNNI1 antibody (ABIN7882280)

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNNI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TNNI1 Antibody

Purpose: TNNI1 Antibody / Troponin I slow skeletal muscle

Sequence: REAEKVRYLA ERIPTLQTR

Purification: Antigen affinity purified

Immunogen: Amino acids REAEKVRYLAERIPTLQTR were used as the immunogen for the TNNI1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TNNI1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TNNI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TNNI1

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Alternative Name: TNNI1

Background: Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

UniProt: P19237