Recombinant Sorting Nexin 4 antibody

Catalog No. ABIN7882338

This Rabbit Monoclonal antibody specifically detects Sorting Nexin 4 in WB and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant Sorting Nexin 4 antibody (ABIN7882338)

Target: Sorting Nexin 4 (SNX4)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Sorting Nexin 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 30S54

Product Details anti-Sorting Nexin 4 Antibody

Purpose: SNX4 Antibody / Sorting nexin 4

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human SNX4 was used as the immunogen for the SNX4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SNX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the SNX4 antibody at -20oC.

Target Details for Sorting Nexin 4

Target: Sorting Nexin 4 (SNX4)

Alternative Name: SNX4

Background: SNX4 antibody detects sorting nexin 4, a member of the sorting nexin family encoded by the SNX4 gene. Sorting nexins are characterized by the presence of a phox homology domain that binds phosphoinositides, enabling association with endosomal membranes. SNX4 is primarily involved in endosomal trafficking, cargo sorting, and membrane remodeling. By directing proteins to recycling or degradative pathways, SNX4 maintains cellular homeostasis and regulates receptor signaling.

SNX4 antibody is widely applied in studies of membrane trafficking, endocytosis, and signal transduction. Sorting nexin 4 is part of the retromer independent recycling pathway and contributes to the trafficking of proteins such as the transferrin receptor. Disruption of SNX4 function impairs endosomal sorting and alters nutrient uptake, receptor turnover, and intracellular signaling dynamics. By detecting SNX4, researchers can explore how sorting nexins control endosomal recycling and cell surface composition.

In western blot assays, SNX4 antibody detects protein bands of the expected size in cell and tissue extracts. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence maps SNX4 distribution on endosomal membranes. These methods support detailed analysis of endosomal dynamics.

SNX4 has been implicated in neurodegenerative disease and cancer. Altered expression affects autophagy, mitochondrial function, and neuronal survival. In oncology, abnormal SNX4 activity influences growth factor receptor trafficking and signaling, potentially affecting tumor progression. By applying SNX4 antibody, scientists can investigate how sorting nexin mediated trafficking pathways contribute to both normal physiology and disease.

SNX4 antibody from NSJ Bioreagents provides dependable specificity for exploring membrane trafficking and signaling. Its versatility across assays makes it an essential reagent for cell biology and disease related research.

UniProt: O95219