Spectrin beta Chain, Erythrocyte (SPTB) antibody

Catalog No. ABIN7882348

The Mouse Monoclonal anti-Spectrin beta Chain, Erythrocyte antibody is suitable to detect Spectrin beta Chain, Erythrocyte in samples from Human. It has been validated for WB, IF and IHC (p).

Quick Overview for Spectrin beta Chain, Erythrocyte (SPTB) antibody (ABIN7882348)

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RG-26

Product Details

Purpose: SPTB Antibody / Spectrin beta

Purification: Protein G affinity chromatography

Immunogen: Red cell membranes were used as the immunogen for this Spectrin beta antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the SPTB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the SPTB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Alternative Name: SPTB

Background: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.

UniProt: P11277

Pathways: Regulation of Actin Filament Polymerization