Recombinant TAO Kinase 1 (TAOK1) antibody

Catalog No. ABIN7882426

The Rabbit Monoclonal anti-TAO Kinase 1 antibody is suitable to detect TAO Kinase 1 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Recombinant TAO Kinase 1 (TAOK1) antibody (ABIN7882426)

Target: TAO Kinase 1 (TAOK1)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Clone: 30T29

Product Details

Purpose: TAOK1 Antibody / Thousand and one amino acid protein kinase 1

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TAOK1 was used as the immunogen for the TAOK1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TAOK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the TAOK1 antibody at -20oC.

Target Details

Target: TAO Kinase 1 (TAOK1)

Alternative Name: TAOK1

Background: TAOK1 antibody detects thousand and one amino acid protein kinase 1, a serine threonine kinase encoded by the TAOK1 gene. TAOK1 belongs to the MAP kinase kinase kinase family and regulates diverse cellular processes including cytoskeletal organization, stress signaling, and apoptosis. Through phosphorylation of downstream MAP kinases, TAOK1 influences cell cycle progression and response to environmental stress.

TAOK1 antibody is widely used in studies of kinase signaling, neuronal development, and cancer biology. In neurons, TAOK1 has been linked to axon outgrowth, dendritic branching, and synaptic plasticity. Mutations and altered expression of TAOK1 have been implicated in neurodevelopmental disorders including autism spectrum disorder. By detecting TAOK1, researchers can evaluate how changes in kinase signaling contribute to brain development and function.

The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect bands corresponding to TAOK1 isoforms across different tissues. Immunohistochemistry highlights expression in developing brain regions, while immunofluorescence provides subcellular localization at cytoskeletal structures and kinases in signaling complexes.

TAOK1 also regulates apoptotic pathways through activation of stress activated protein kinases. It contributes to programmed cell death under stress conditions, linking it to cancer and degenerative disease. Elevated TAOK1 expression has been reported in tumors, where it may affect proliferation and survival pathways. By applying TAOK1 antibody, scientists can study its role in balancing survival and death signals in health and disease.

TAOK1 antibody from NSJ Bioreagents offers dependable specificity for analyzing MAP kinase signaling, neuronal development, and oncogenesis. Its performance across applications makes it a valuable reagent for laboratories studying cellular stress responses and growth regulation.

UniProt: Q7L7X3