Recombinant TSH receptor antibody

Catalog No. ABIN7882482

This Rabbit Monoclonal antibody specifically detects TSH receptor in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant TSH receptor antibody (ABIN7882482)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TSH receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TSHRB-1607R

Product Details anti-TSH receptor Antibody

Purpose: Recombinant TSH Receptor Antibody / B-Chain

Purification: Protein A/G affinity

Immunogen: Recombinant human TSHR B-Chain protein was used as the immunogen for the recombinant TSH Receptor antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant TSH Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant TSH Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Alternative Name: TSH Receptor

Background: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

UniProt: P16473

Pathways: Thyroid Hormone Synthesis