Recombinant TSHB antibody

Catalog No. ABIN7882483

The Rabbit Monoclonal anti-TSHB antibody is suitable to detect TSHB in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant TSHB antibody (ABIN7882483)

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TSHB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TSHb-7001R

Product Details anti-TSHB Antibody

Purpose: Recombinant TSH beta Antibody / TSHB (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant human TSH beta protein fragment was used as the immunogen for the recombinant TSH beta antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant TSH beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant TSH beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TSHB

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Alternative Name: TSH beta

Background: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

UniProt: P01222

Pathways: Thyroid Hormone Synthesis, Peptide Hormone Metabolism