TSHB antibody

Catalog No. ABIN7882485

This Mouse Monoclonal antibody specifically detects TSHB in IHC (p). It exhibits reactivity toward Human.

Quick Overview for TSHB antibody (ABIN7882485)

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TSHB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TSHb-1317

Product Details anti-TSHB Antibody

Purpose: TSHB Antibody / TSH beta (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein was used as the immunogen for this TSHB antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the TSHB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the TSHB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TSHB

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Alternative Name: TSHB

Background: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH) follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

UniProt: P01222

Pathways: Thyroid Hormone Synthesis, Peptide Hormone Metabolism