Recombinant TOR4A antibody

Catalog No. ABIN7882508

The Rabbit Monoclonal anti-TOR4A antibody (Clone 29T65) (ABIN7882508) specifically detects TOR4A in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant TOR4A antibody (ABIN7882508)

Target: TOR4A (Torsin Family 4, Member A (TOR4A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TOR4A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 29T65

Product Details anti-TOR4A Antibody

Purpose: TOR4A Antibody / Torsin family 4 member A

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human TOR4A was used as the immunogen for the TOR4A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TOR4A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the TOR4A antibody at -20oC.

Target Details for TOR4A

Target: TOR4A (Torsin Family 4, Member A (TOR4A))

Alternative Name: TOR4A

Background: TOR4A antibody detects Torsin family 4 member A, encoded by the TOR4A gene. Torsin family 4 member A is a member of the AAA+ ATPase family of proteins, localized to the endoplasmic reticulum and nuclear envelope. TOR4A antibody provides researchers with a useful reagent to study endoplasmic reticulum biology, protein homeostasis, and nuclear envelope function.

Torsin family 4 member A is part of a family of ATPases that contribute to protein folding, trafficking, and quality control. Research using TOR4A antibody has shown that the protein supports structural organization of the endoplasmic reticulum and nuclear envelope. By interacting with other torsin proteins, TOR4A participates in maintaining organelle integrity and proteostasis under basal and stress conditions.

Studies with TOR4A antibody have revealed that the protein is involved in nuclear envelope structure and potentially nuclear pore dynamics. Disruption of torsin family proteins has been linked to nuclear envelope abnormalities and impaired nucleocytoplasmic transport. These findings suggest that TOR4A contributes to essential processes that support gene regulation and cell signaling.

Dysregulation of TOR4A has been implicated in disease. Research using TOR4A antibody has shown associations with cancer progression and viral infection. Overexpression in certain cancers correlates with altered protein folding capacity and stress adaptation, while some pathogens exploit torsin family proteins for replication. These findings underscore the relevance of TOR4A in health and pathology.

TOR4A antibody is commonly applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous protein levels, immunohistochemistry reveals tissue-specific expression, and immunofluorescence demonstrates localization to the endoplasmic reticulum and nuclear envelope. These applications make TOR4A antibody valuable for cell biology research.

By providing validated TOR4A antibody reagents, NSJ Bioreagents supports studies into organelle biology, stress responses, and disease. Detection of Torsin family 4 member A provides insights into how AAA+ ATPases contribute to proteostasis and nuclear structure.

UniProt: Q9NXH8