Recombinant TIMM44 antibody

Catalog No. ABIN7882540

The Rabbit Monoclonal anti-TIMM44 antibody is suitable to detect TIMM44 in samples from Human and Rat. It has been validated for WB, IF, ICC, IP and FACS.

Quick Overview for Recombinant TIMM44 antibody (ABIN7882540)

Target: TIMM44 (Translocase of Inner Mitochondrial Membrane 44 (TIMM44))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TIMM44 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: 30T70

Product Details anti-TIMM44 Antibody

Purpose: TIMM44 Antibody / Translocase of inner mitochondrial membrane 44

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human TIM44 was used as the immunogen for the TIMM44 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TIMM44 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the TIMM44 antibody at -20oC.

Target Details for TIMM44

Target: TIMM44 (Translocase of Inner Mitochondrial Membrane 44 (TIMM44))

Alternative Name: TIMM44

Background: TIM44 antibody recognizes translocase of inner mitochondrial membrane 44, a central component of the mitochondrial protein import machinery. TIM44 anchors mitochondrial Hsp70 to the inner membrane, enabling preprotein translocation through the TIM23 complex. By facilitating proper protein targeting, TIM44 ensures mitochondrial biogenesis and maintenance of energy production.

Research using TIM44 antibody has highlighted its importance in mitochondrial function and human disease. Altered expression of TIM44 can impair protein import, leading to mitochondrial stress and metabolic dysfunction. Dysregulation has been linked to neurodegenerative conditions, where defective energy metabolism is a hallmark, and to metabolic syndromes associated with impaired mitochondrial quality control.

Validated clones for TIM44 detection are suitable for western blot, immunofluorescence, and immunohistochemistry. These reagents allow investigators to track mitochondrial protein import efficiency and examine changes in response to cellular stress. Monitoring TIM44 levels provides valuable insight into how cells adapt to demands on mitochondrial biogenesis and oxidative metabolism.

NSJ Bioreagents offers this TIM44 antibody to support studies in mitochondrial biology, metabolic regulation, and disease. Alternate names include translocase of inner mitochondrial membrane 44 antibody, mitochondrial import receptor subunit TIM44 antibody, and HSP-binding protein antibody.

UniProt: O43615