Recombinant TMEM43 antibody

Catalog No. ABIN7882550

The Rabbit Monoclonal anti-TMEM43 antibody (Clone 30T30) (ABIN7882550) specifically detects TMEM43 in WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant TMEM43 antibody (ABIN7882550)

Target: TMEM43 (Transmembrane Protein 43 (TMEM43))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TMEM43 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 30T30

Product Details anti-TMEM43 Antibody

Purpose: TMEM43 Antibody / Transmembrane protein 43 / LUMA

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human TMEM43 was used as the immunogen for the TMEM43 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TMEM43 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the TMEM43 antibody at -20oC.

Target Details for TMEM43

Target: TMEM43 (Transmembrane Protein 43 (TMEM43))

Alternative Name: TMEM43

Background: TMEM43 antibody detects Transmembrane protein 43, also called Protein LUMA, encoded by the TMEM43 gene. Transmembrane protein 43 is an inner nuclear membrane protein that contributes to nuclear architecture, signaling, and mechanotransduction. TMEM43 antibody provides researchers with a useful tool to study nuclear envelope biology, cardiomyopathy, and cellular signaling pathways.

Transmembrane protein 43 is highly conserved and associates with lamins and emerin within the nuclear envelope. Research using TMEM43 antibody has shown that it supports structural integrity of the nucleus and contributes to chromatin organization. TMEM43 interacts with protein complexes that link the nucleoskeleton to the cytoskeleton, enabling cells to respond to mechanical stimuli and maintain nuclear shape.

Studies with TMEM43 antibody have revealed that it plays essential roles in cardiac physiology. Mutations in the TMEM43 gene cause arrhythmogenic right ventricular cardiomyopathy, a hereditary disorder characterized by fibrofatty replacement of myocardium and increased risk of sudden cardiac death. Research into disease associated variants has demonstrated that loss of nuclear stability and altered signaling underlie this pathology. These findings highlight the importance of TMEM43 in maintaining cardiac health.

In addition to cardiovascular roles, Transmembrane protein 43 contributes to gene regulation. Research using TMEM43 antibody has indicated that nuclear envelope localization allows it to modulate transcription by influencing chromatin anchoring and positioning within the nucleus. These structural and regulatory functions make TMEM43 a multifunctional nuclear protein.

Dysregulation of TMEM43 is also linked to cancer. Studies with TMEM43 antibody have shown that changes in expression affect nuclear signaling pathways and may promote malignant transformation. Altered nuclear structure and mechanics, driven by TMEM43 dysfunction, contribute to abnormal growth and migration. These findings underscore the importance of nuclear envelope proteins in tumor biology.

TMEM43 antibody is commonly used in western blotting, immunofluorescence, and immunohistochemistry. Western blotting detects endogenous protein levels, immunofluorescence highlights localization to the nuclear envelope, and immunohistochemistry reveals tissue distribution in muscle and cardiac tissues. These applications make TMEM43 antibody valuable for nuclear biology and disease studies.

By providing validated TMEM43 antibody reagents, NSJ Bioreagents supports research into nuclear envelope function, cardiomyopathy, and cancer. Detection of Transmembrane protein 43 provides insight into how structural proteins maintain nuclear integrity and influence disease.

UniProt: Q9BTV4