TFF1 antibody

Catalog No. ABIN7882565

The Rabbit Polyclonal anti-TFF1 antibody (ABIN7882565) specifically detects TFF1 in WB and IF. The antibody is reactive with Human samples.

Quick Overview for TFF1 antibody (ABIN7882565)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TFF1 Antibody

Purpose: Estrogen Inducible Protein pS2 Antibody / TFF1

Sequence: FYPNTIDVPP EEECEF

Purification: Antigen affinity purified

Immunogen: Amino acids FYPNTIDVPPEEECEF from the human protein were used as the immunogen for the Estrogen Inducible Protein pS2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Estrogen Inducible Protein pS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Estrogen Inducible Protein pS2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Alternative Name: Estrogen Inducible Protein pS2

Background: TFF1 (Trefoil factor 1), also known as pS2, is a protein that in humans is encoded by the TFF1 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. It is found that TFF1 in normal human urine inhibited the growth of calcium oxalate crystals. Urinary TFF1 showed an inhibitory potency similar to that of nephrocalcin, and inhibition was dose dependent and inhibited by TFF1 antisera, particularly by antisera directed to the TFF1 C terminus. Concentrations and relative amounts of TFF1 in the urine of patients with idiopathic calcium oxalate kidney stones were significantly less than those found in controls. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

UniProt: P04155

Pathways: EGFR Signaling Pathway