Troponin I antibody

Catalog No. ABIN7882571

The Rabbit Polyclonal anti-Troponin I antibody (ABIN7882571) specifically detects Troponin I in WB. The antibody is reactive with Rat and Mouse samples.

Quick Overview for Troponin I antibody (ABIN7882571)

Target: Troponin I (TNNI)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Troponin I antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Troponin I Antibody

Purpose: Troponin I Antibody / TNNI3

Sequence: MMQALLGARA KESLDLRAHL KQ

Purification: Antigen affinity purified

Immunogen: Amino acids MMQALLGARAKESLDLRAHLKQ were used as the immunogen for the Troponin I antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Troponin I antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Troponin I antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Troponin I

Target: Troponin I (TNNI)

Alternative Name: Troponin I

Background: Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.

UniProt: P19429