Recombinant UFC1 antibody

Catalog No. ABIN7882632

This Rabbit Monoclonal antibody specifically detects UFC1 in WB, IHC, IF, ICC and IP. It exhibits reactivity toward Human.

Quick Overview for Recombinant UFC1 antibody (ABIN7882632)

Target: UFC1 (Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This UFC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Clone: 30U27

Product Details anti-UFC1 Antibody

Purpose: UFC1 Antibody / Ubiquitin-fold modifier conjugating enzyme 1

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Ubiquitin-fold modifier conjugating enzyme 1 protein was used as the immunogen for the UFC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the UFC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the UFC1 antibody at -20oC.

Target Details for UFC1

Target: UFC1 (Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1))

Alternative Name: UFC1

Background: UFC1 antibody detects ubiquitin-fold modifier conjugating enzyme 1, an essential component of the UFM1 conjugation system. UFC1 functions as an E2-like enzyme that transfers UFM1 to substrate proteins, regulating diverse cellular processes such as ER homeostasis, stress responses, and protein quality control. The UFM1 pathway resembles ubiquitination but is distinct, making UFC1 a unique player in post-translational modification networks.

Research using UFC1 antibody has shown that defects in UFM1 conjugation can impair ER stress management and contribute to diseases including cancer and metabolic disorders. Variations in UFC1 function may alter cell survival and proliferation, and the pathway has been linked to hematopoietic development and cardiac physiology. Because UFMylation is less understood than ubiquitination, ongoing studies continue to reveal novel roles for UFC1 in cellular regulation.

Antibodies against UFC1 are validated for applications such as western blot, immunoprecipitation, and immunohistochemistry. These reagents allow researchers to track UFC1 expression levels and to explore its role in the transfer of UFM1 during cellular stress. Clone-specific performance provides consistency for labs investigating this unique modification pathway.

NSJ Bioreagents offers this UFC1 antibody to support research into UFMylation, protein quality control, and disease mechanisms. Alternate names include ubiquitin-fold modifier conjugating enzyme 1 antibody, UFM1-conjugating enzyme antibody, and UBC-E2 antibody.

UniProt: Q9Y3C8