UCP3 antibody

Catalog No. ABIN7882641

This Rabbit Polyclonal antibody specifically detects UCP3 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for UCP3 antibody (ABIN7882641)

Target: UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UCP3 Antibody

Purpose: UCP3 Antibody / SLC25A9

Sequence: LDTAKVRLQI QGENQAVQTA RLVQYR

Purification: Antigen affinity purified

Immunogen: Amino acids LDTAKVRLQIQGENQAVQTARLVQYR were used as the immunogen for the UCP3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the UCP3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the UCP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for UCP3

Target: UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Alternative Name: UCP3

Background: Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression, this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.

UniProt: P55916

Pathways: Proton Transport