Vitamin D Receptor antibody

Catalog No. ABIN7882684

The Rabbit Monoclonal anti-Vitamin D Receptor antibody is suitable to detect Vitamin D Receptor in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Vitamin D Receptor antibody (ABIN7882684)

Target: Vitamin D Receptor (VDR)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Vitamin D Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AAGE-22

Product Details anti-Vitamin D Receptor Antibody

Purpose: Vitamin D Receptor Antibody / VDR

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Vitamin D Receptor / VDR was used as the immunogen for the Vitamin D Receptor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Vitamin D Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Vitamin D Receptor antibody at -20oC.

Target Details for Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Alternative Name: Vitamin D Receptor

Target Type: Chemical

Background: The VDR gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [RefSeq]

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway