Vitronectin Receptor antibody
The Mouse Monoclonal anti-Vitronectin Receptor antibody (Clone 23C6) (ABIN7882688) specifically detects Vitronectin Receptor in ELISA.
The antibody is reactive with Human samples.
Catalog No. ABIN7882688
$317.38
Plus shipping costs $50.00
20 μg
Shipping to:
United States
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Quick Overview for Vitronectin Receptor antibody (ABIN7882688)
Target
Vitronectin Receptor
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Conjugate
Un-conjugated
Application
ELISA
Clone
23C6
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Purpose
- Vitronectin Receptor Antibody / Integrin alpha V / ITGAV
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Purification
- Protein G affinity chromatography
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Immunogen
- Osteoclasts from osteoclastomas were used as the immunogen for the Vitronectin Receptor antibody.
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Isotype
- IgG1, kappa
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Application Notes
- Optimal dilution of the Vitronectin Receptor antibody should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.2 mg/mL
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Buffer
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store the Vitronectin Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Vitronectin Receptor
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Background
- ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
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UniProt
- P06756
Target
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