AQP11 antibody (2nd Extracellular Loop)

Catalog No. ABIN7884764

The Rabbit Polyclonal anti-AQP11 antibody (ABIN7884764) specifically detects AQP11 in WB. The antibody is reactive with Mouse and Rat samples.

Quick Overview for AQP11 antibody (2nd Extracellular Loop) (ABIN7884764)

Target: AQP11 (Aquaporin 11 (AQP11))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AQP11 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-AQP11 Antibody

Binding Specificity: 2nd Extracellular Loop, AA 140-151

Purpose: A Rabbit Polyclonal Antibody to Aquaporin 11 Channel

Predicted Reactivity: Mouse - 11,12 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)SLSLTKYHFDER, corresponding to amino acid residues 140-151 of rat AQP11

Isotype: IgG

Application Details

Application Notes:

WB: 1:1000

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7234755)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for AQP11

Target: AQP11 (Aquaporin 11 (AQP11))

Alternative Name: AQP11

Background:

Synonyms: AQP11

Description: The aquaporins (AQP), also known as the major intrinsic protein superfamily (MIP), are a family of integral membrane proteins. In mammals, 13 aquaporins were described (AQP0-AQP12). Aquaporin 11 (AQP11) is a newly described member of the aquaporins family. Aquaporin 11 (AQP11) has been identified with unusual pore-forming NPA (asparagine-proline-alanine) boxes. AQP11 presents a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1. There are two subfamilies: the aquaporins, which transport only water and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water2.Aquaporins and aquaglyceroporins are ubiquitously expressed, including in the plasma membrane of renal epithelia, brain astrocytes, and red blood cells3. AQP11 is expressed in several tissues including testis, kidney, liver, and brain. In the brain, AQP11 is found in Purkinje cells, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons4. In the kidney AQP11 has a central role in vesicular homeostasis as demonstrated in experiments using AQP11 knockout mice which display growth retardation and progressively die before weaning. The cause of death seems to be advanced renal failure5.

Gene ID: 286758

UniProt: Q8CHM1