Aquaporin 5 antibody (C-Term, Intracellular)

Catalog No. ABIN7884769

The Rabbit Polyclonal anti-Aquaporin 5 antibody is suitable to detect Aquaporin 5 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, IF and IC.

Quick Overview for Aquaporin 5 antibody (C-Term, Intracellular) (ABIN7884769)

Target: Aquaporin 5 (AQP5)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aquaporin 5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Grade: Carrier-free

Product Details anti-Aquaporin 5 Antibody

Binding Specificity: AA 251-265, C-Term, Intracellular

Purpose: A Rabbit Polyclonal Antibody to Aquaporin 5 Channel

Predicted Reactivity: Mouse - identical, human - 10,16 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DHREERKKTIELTAH corresponding to amino acid residues 251-265 of rat AQP5

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7234767)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Aquaporin 5

Target: Aquaporin 5 (AQP5)

Alternative Name: AQP5

Background:

Synonyms: AQP5

Description: The importance of the aquaporin water channels was underscored by awarding the 2003 Nobel Prize in Chemistry to Peter Agre "for the discovery of water channels". Today, eleven mammalian proteins that belong to the aquaporin family have been identified. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. Aquaporin 5 (AQP5) is expressed in secretory glands, lung and eye, where it works in modulating the rate of fluid release. Since a number of pathological conditions including pulmonary edema, respiratory distress syndrome and congestive heart failure are characterized by disrupted fluid transport, it has been suggested that modulation of the expression of AQP5 could be a novel modality of treatment of the above illnesses. Indeed, several studies have shown that AQP5 expression is downregulated in animal models of acute lung infection.

Gene ID: 25241

UniProt: P47864