Aquaporin 7 antibody (Intracellular, N-Term)

Catalog No. ABIN7884771

This Rabbit Polyclonal antibody specifically detects Aquaporin 7 in WB, IHC, IF and IC. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Aquaporin 7 antibody (Intracellular, N-Term) (ABIN7884771)

Target: Aquaporin 7 (AQP7)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aquaporin 7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Grade: Carrier-free

Product Details anti-Aquaporin 7 Antibody

Binding Specificity: AA 7-24, Intracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Aquaporin 7 Channel

Predicted Reactivity: 18 amino acid residues identical,Mouse - 15, human - 11

Purification: Affinity purified on immobilized antigen.

Immunogen: ENIQSVLQKTWVREFLAE, corresponding to amino acid residues 7-24 of rat AQP7

Isotype: IgG

Application Details

Application Notes:

WB: 1:500

FC: The optimal concentration should be determined by the user

ICC: 1:800

IHC: 1:100

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7234775)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Aquaporin 7

Target: Aquaporin 7 (AQP7)

Alternative Name: AQP7

Background:

Synonyms: AQP7, Aquaglyceroporin-7, AQPap, Aquaporin adipose

Description: Aquaporin 7 (AQP-7) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12). Little is known about the function of the two newest members, AQP-11 and AQP-12.The aquaporins can be divided into two functional groups based on their permeability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-7, AQP-3, AQP-9 and AQP-10.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit contains four pores.AQP-7 is expressed in ovary, testis, kidney and adipose tissue.The function of AQP-7 in adipose tissue attracted much interest as mice deficient in AQP-7 developed adult-onset obesity and Type 2 Diabetes. AQP-7 modulates adipocyte glycerol permeability thereby controlling triglyceride accumulation and fat cell size.

Gene ID: 29171

UniProt: P56403